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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

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[Common Variable Immunodeficiency as a Multisystem Disorder - A Case Report].

Shira Benor1, David Hagin1

  • 1Allergy and Clinical Immunology Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Harefuah
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

Common Variable Immunodeficiency (CVID) is a primary immunodeficiency often causing infections and immune dysregulation. This case highlights CVID

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Area of Science:

  • Immunology
  • Clinical Medicine
  • Genetics

Background:

  • Common Variable Immunodeficiency (CVID) is the most frequent primary immunodeficiency, characterized by hypogammaglobulinemia and recurrent infections.
  • CVID involves impaired B-cell function, leading to reduced antibody production and response to neo-antigens.
  • Beyond infections, CVID can manifest with immune dysregulation, including autoimmunity and lymphoproliferation, potentially complicating diagnosis and treatment.

Purpose of the Study:

  • To describe a complex case of Common Variable Immunodeficiency (CVID) with significant immune dysregulation.
  • To discuss the diagnostic and therapeutic challenges associated with non-infectious complications of CVID.
  • To emphasize the need for a multidisciplinary approach in managing CVID as a multi-organ disorder.

Main Methods:

  • Case report detailing a patient with complicated CVID.
  • Review of diagnostic workup for immune dysregulation in CVID.
  • Discussion of treatment strategies for non-infectious complications in immunocompromised patients.

Main Results:

  • The presented case illustrates diverse immune dysregulation aspects in CVID.
  • Non-infectious CVID complications can precede or dominate the clinical picture, delaying diagnosis.
  • Treatment of non-infectious CVID manifestations requires careful consideration due to the patient's immunocompromised state.

Conclusions:

  • CVID is a complex multi-organ disorder requiring a holistic management strategy.
  • A multidisciplinary team approach is crucial for effectively managing CVID and its complications.
  • Awareness of CVID's diverse presentations is essential for timely diagnosis and optimal patient care.