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The role of miRNA in modulating oxidative stress in preeclampsia: current knowledge

Chao Lin1,2, Qiang Xu1, Jinye Yan1

  • 1National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China.

RNA Biology
|May 27, 2026
PubMed

Insights

Preeclampsia, a pregnancy disorder, involves oxidative stress regulated by microRNAs (miRNAs). This review explores how miRNAs impact preeclampsia development and offers insights into potential miRNA-targeted therapies.

Area of Science:

  • Obstetrics and Gynecology
  • Molecular Biology
  • Biochemistry

Background:

  • Preeclampsia (PE) is a major global cause of maternal and perinatal mortality.
  • Hypertension and proteinuria are key diagnostic markers for PE.
  • Oxidative stress (OS) significantly contributes to PE progression.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in preeclampsia development.
  • To focus on the involvement of miRNAs in regulating oxidative stress in PE.
  • To discuss molecular mechanisms and potential therapeutic strategies targeting miRNAs for PE.

Main Methods:

  • Literature review of studies on miRNAs, oxidative stress, and preeclampsia.
  • Analysis of molecular mechanisms underlying miRNA regulation in PE.
  • Synthesis of current knowledge on therapeutic implications of targeting miRNAs.

Main Results:

  • Multiple miRNAs are implicated in the progression of preeclampsia.
  • miRNAs play a crucial role in modulating oxidative stress pathways relevant to PE.
  • Specific miRNAs influence gene expression post-transcriptionally, affecting PE pathogenesis.

Conclusions:

  • miRNAs are key regulators of oxidative stress in preeclampsia.
  • Targeting specific miRNAs presents a promising therapeutic avenue for managing PE.
  • Further research into miRNA-mediated mechanisms can advance PE treatment strategies.

Keywords:
mechanismsmiRNAoxidative stressplacentapreeclampsia

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