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Related Experiment Video

Updated: May 28, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

When Pacing Fails After Generator Replacement: A Stepwise Diagnostic Approach to a Reversible Lead-Header Interface

Fulvio Cacciapuoti¹, Antonietta Buonomo², Salvatore Crispo¹

¹Division of Cardiology "Antonio Cardarelli" Hospital, 80131 Naples, Italy.

|May 27, 2026

Summary

Early pacemaker pacing failure after generator replacement may not indicate lead damage. A stepwise diagnostic approach, including unipolar vs. bipolar pacing, can identify reversible causes, avoiding unnecessary lead interventions.

Area of Science:

Cardiology
Biomedical Engineering
Medical Device Technology

Background:

Keywords:

device interrogation generator replacement lead malfunction loss of capture pacemaker malfunction unipolar pacing

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Early loss of pacing capture post-pacemaker generator replacement is rare but critical, especially in pacemaker-dependent patients.
Device malfunction is often presumed to be lead damage, leading to invasive procedures.
However, reversible causes of pacing failure exist and can be identified through careful device interrogation.