Related Experiment Video
Updated: May 28, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Diastereoselective assembly of complex benzofuran-annulated spiro-tetrahydroquinoline frameworks via Povarov
Amir Rashid Tarray1,2,3, Ayshia Naaz1,3, Tulsi R Patel4
1Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine (IIIM), Jammu, Jammu and Kashmir 180001, India. showkat.rashid@iiim.res.in.
Abstract:
A Sc(OTf)3/HFIP-catalyzed annulation of isatins, anilines and 3-methylbenzofurans has been developed for the diastereoselective synthesis of spiro-tetrahydroquinolines. The reaction proceeds via a regioselectively reversed Povarov reaction as established through DFT calculations. Broad substrate scope, high functional-group tolerance, and gram-scale applicability are the key highlights of this strategy.
Related Concept Videos
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Cycloaddition Reactions: Overview
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
Aromatic Hydrocarbon Cations: Structural Overview
Removing one hydrogen from the intervening CH2 group with both...
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
