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Published on: March 13, 2019
Unlocking a modular Gd-DOTBA platform via tetramaleimide click chemistry for high-performance MRI
Xinhui Xiao1,2, Shiyao Wang1, Peijie Guan1,2
1Department of Radiology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China. cn_boy2000@wmu.edu.cn.
Chemical Communications (Cambridge, England)
|May 27, 2026
Abstract
None:
A tetramaleimide-functionalized Gd-DOTBA scaffold (Gd-DOTBA-Mal) is developed as a modular platform for high-performance MRI probes. The maleimide groups enable site-specific bioconjugation. A cysteine conjugate exhibits high relaxivity and stability, enabling sensitive kidney dysfunction assessment and tumor imaging at half the clinical dose. This versatile platform facilitates advanced molecular MRI development.
