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Mild functional impairment: Definition and diagnostic criteria.
M S Manzano Palomo1, C Terrón Cuadrado2, M J Gil Moreno3
1Servicio de Neurología, Hospital Universitario Infanta Leonor, Universidad Complutense de Madrid, Grupo de Estudio de Neurogeriatría Sociedad Española de Neurología, Madrid, Spain.
Neurologia
|May 27, 2026
Summary
Researchers defined mild functional impairment (MFI) using a multidisciplinary approach. This new definition aims to improve early assessment of functional changes linked to neurodegenerative diseases and aging.
Area of Science:
- Gerontology
- Neurology
- Clinical Medicine
Background:
- Mild functional impairment (MFI) is linked to cognitive decline and impacts neurological, psychiatric, and geriatric conditions.
- A clear definition for MFI is currently lacking, hindering its impact analysis.
Purpose of the Study:
- To establish diagnostic criteria for defining the mild functional impairment (MFI) construct.
- To create a standardized definition through expert consensus and evidence review.
Main Methods:
- A multidisciplinary team reviewed scientific evidence to propose MFI criteria.
- The Delphi methodology was employed to refine the construct, considering physical, cognitive, and behavioral aspects.
- Key discussion points included temporal occurrence, age of application, persistence, affected activities, and need for aids.
Main Results:
- A defined construct for MFI was generated, encompassing physical, cognitive, and behavioral domains.
- Consensus was reached on critical aspects for defining MFI, including its temporal aspects and impact on daily living.
Conclusions:
- The defined MFI construct facilitates early assessment of functional changes potentially related to neurodegenerative diseases and aging.
- This definition will serve as a foundation for developing tools for accurate functional assessment in adult patients.
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