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Related Concept Videos

The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Lifestyle Factors and Health01:20

Lifestyle Factors and Health

Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
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Introduction to Epidemiology01:26

Introduction to Epidemiology

Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...

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Related Experiment Video

Updated: May 29, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

A population-based study on the association between periodontitis, flossing behavior, and mortality.

Xu-Fang Liu1, Yuan-Yuan Li1, Sai Ma1

  • 1National Clinical Research Center for Oral Diseases, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.

Journal of Dentistry
|May 27, 2026
PubMed
Summary

Regular dental flossing is linked to a lower risk of all-cause mortality, showing a dose-response relationship. This association holds even for individuals with periodontitis, suggesting flossing is a beneficial preventive habit.

Keywords:
Flossing behaviorMortalityOral hygienePeriodontitis

Related Experiment Videos

Last Updated: May 29, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Area of Science:

  • Public Health
  • Epidemiology
  • Preventive Medicine

Background:

  • Dental flossing is recognized for improving oral hygiene.
  • The impact of flossing on overall health and mortality risk is less understood.
  • Periodontitis is a known risk factor for various systemic conditions.

Purpose of the Study:

  • To investigate the association between flossing frequency and all-cause mortality.
  • To determine the dose-response relationship between flossing and mortality risk.
  • To evaluate the combined effect of periodontitis and flossing on mortality.

Main Methods:

  • Analysis of 10,609 participants from the U.S. National Health and Nutrition Examination Survey (2009-2014).
  • Utilized inverse probability of treatment weighting and Cox proportional hazards regression.
  • Employed a restricted cubic spline model to assess dose-response relationships.

Main Results:

  • Any flossing was associated with a 29.6% reduction in mortality risk.
  • A significant inverse dose-response was observed, with daily flossing showing the lowest risk.
  • Individuals with periodontitis and no flossing had the highest mortality risk, which was attenuated by flossing.

Conclusions:

  • An inverse dose-response association exists between flossing frequency and all-cause mortality.
  • This association was evident even in participants with periodontitis.
  • Findings are hypothesis-generating due to observational nature and potential for residual confounding.