The Use of ICSI for Non-Male Factor Infertility: A Multicentre, Cross-Sectional Study

Area of Science:

• Reproductive Medicine
• In Vitro Fertilization (IVF)

Background:

• Intracytoplasmic sperm injection (ICSI) is increasingly used for non-male factor infertility (NMFI).
• Patient perspectives on ICSI for NMFI are not well understood.

Purpose of the Study:

• To assess patient attitudes and preferences regarding ICSI for NMFI in IVF.
• To understand the drivers behind ICSI utilization in cases without male factor infertility.

Main Methods:

• A multicenter, cross-sectional online survey was conducted.
• 123 participants with NMFI planning their first IVF treatment were included.
• Exclusion criteria included male factor infertility, gamete donation, PGT, and cryopreserved oocyte use.

Main Results:

• 59% of participants were familiar with fertilization techniques; 34% believed ICSI offered the best chance of conception.
• Most participants (85%) had no contraindications to ICSI.
• The majority (55%) preferred their physician's recommendation.

Conclusions:

• Patient attitudes and preferences do not appear to drive the increased use of ICSI for NMFI.
• Fertility specialists should reconcile current practices with scientific evidence.