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Published on: August 2, 2024
Pathophysiology of Cough
Peter S Giannaris1, Seth E Kaplan2
1Department of Otolaryngology-Head and Neck Surgery, Lenox Hill Hospital/Northwell Health, 130 East 77th Street Black Hall, 10th Floor, New York, NY 10075, USA.
None:
Cough pathophysiology ranges from a simple reflex to a complex neuroimmune disorder involving intricate neural circuitry, peripheral sensitization, and central plasticity. The cough reflex is governed by a complex orchestration of sensory nerves and central brain structures. Chronic cough often results from peripheral and central sensitization, leading to hypersensitivity influenced by various physiologic and environmental factors. This advanced understanding is vital for developing personalized, mechanism-directed therapies for this prevalent condition.
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