Early Recognition of Treatment-Responsive Rapidly Progressive Dementia: The Modified STAM3^mP Score

Early identification of patients with treatment-responsive rapidly progressive dementia (RPD) is important as early treatment improves outcomes. The STAM₃P score identifies treatment-responsive RPD using "high risk" presenting features. We optimized performance by adding a time component (i.e., dementia within 3 months) and validated the modified "STAM3^mP score" in two independent cohorts (n = 302). A STAM3^mP score ≥ 1 identified 96% of patients with treatment-responsive RPD; ≥ 3 features were highly specific (98%). These data suggest that ≥ 1 STAM3^mP features effectively identifies treatment-responsive RPD and may be used to prioritize investigations, whereas ≥ 3 STAM3^mP features are highly specific and may inform early treatment decisions.