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Related Experiment Video

Updated: May 29, 2026

Brain Mapping Using a Graphene Electrode Array
10:32

Brain Mapping Using a Graphene Electrode Array

Published on: October 20, 2023

An artefact-resilient wide bandwidth bidirectional graphene neural interface.

Michał Prokop1, Martín Esparza-Iaizzo2,3, Eduard Masvidal-Codina1,4,5

  • 1Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Barcelona, Spain.

Nature Communications
|May 27, 2026
PubMed

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Summary

This study introduces a novel bidirectional neural interface combining graphene transistors for recording and graphene oxide for stimulation. This hybrid device enables simultaneous neural recording and modulation without compromising performance, paving the way for adaptive neuromodulation therapies.

Area of Science:

  • Neuroscience
  • Materials Science
  • Biomedical Engineering

Background:

  • Bidirectional neural interfaces are crucial for adaptive neuromodulation therapies.
  • Graphene transistor technologies offer promising neural recording capabilities at low frequencies.
  • Existing technologies have limitations in charge injection capacity for stimulation.

Purpose of the Study:

  • To develop a novel bidirectional neural interface integrating graphene-based technologies for simultaneous neural recording and stimulation.
  • To leverage complementary functionalities of reduced graphene oxide (rGO) and graphene solution-gated field-effect transistors (gSGFETs) in a single flexible probe.
  • To evaluate the performance of the hybrid device, particularly transistor function during stimulation.

Main Methods:

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A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats
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A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

Published on: November 7, 2017

Related Experiment Videos

Last Updated: May 29, 2026

Brain Mapping Using a Graphene Electrode Array
10:32

Brain Mapping Using a Graphene Electrode Array

Published on: October 20, 2023

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats
10:41

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

Published on: November 7, 2017

  • Monolithic integration of nanoporous rGO microelectrodes and gSGFETs using scalable microfabrication.
  • Fabrication of fully flexible neural probes.
  • In vitro (saline) and in vivo performance evaluation, focusing on transistor response during stimulation.

    • Main Results:

    • Demonstrated a hybrid device combining focal stimulation and brain activity monitoring.
    • Confirmed that the recording capability, including infraslow and local field potential activity, is maintained during stimulation.
    • Showcased the successful integration of complementary graphene-based technologies on a flexible platform.

    Conclusions:

    • The developed bidirectional neural interface successfully integrates stimulation and recording functionalities without performance compromise.
    • This technology opens new avenues for adaptive neuromodulation therapies, particularly those based on infraslow activity.
    • The flexible, hybrid graphene-based probes offer a promising platform for future neural interface development.