Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Phylogenetic Trees

Phylogenetic Trees

Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.

Phylogenetic Trees

Phylogenetic Trees

Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

Multiple Bar Graph

Multiple Bar Graph

As the name suggests, a multiple bar graph is the same as a bar graph but has multiple bars to depict relationships between different data values. One can include as many parameters as possible. However, each parameter must have the same unit of measurement.
Each bar or column in the multiple bar graph represents a data value. These graphs are used primarily in interrelating two or more sets of data. The categories of different kinds of data are listed along the horizontal or x-axis, whereas...

Phylogeny

Phylogeny

Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.

Bar Graph

Bar Graph

A bar graph is also called a bar chart and consists of bars that are separated from each other. It either uses horizontal or vertical bars to show comparisons among categories. The bars can be rectangles, or they can be rectangular boxes (used in three-dimensional plots). One axis of the graph represents the specific categories being compared, and the other axis shows a discrete value. In this graph, the length of the bar for each category is proportional to the number or percent of individuals...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Coping Strategies and Experiences of Patients With Crohn's Disease During the COVID-19 Epidemic: A Descriptive Phenomenology Study.

Nursing open·2026

Same author

Case report: A challenging case of stage IVB mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder treated with extended radical resection including portal vein reconstruction.

Frontiers in oncology·2026

Same author

Utilization of natural product for developing promising sterol biosynthesis inhibitors: design, synthesis and antifungal evaluation of cyclic trialkylamine derivatives.

Bioorganic chemistry·2026

Same author

Individual variability shapes ex vivo responses to resistant starch in inflammatory bowel disease derived microbiomes.

NPJ biofilms and microbiomes·2026

Same author

Development and internal validation of a nomogram for predicting referral or hospitalization risk in children with community-acquired influenza.

Frontiers in pediatrics·2026

Same author

MetaDIA: A DDA-free Database Reduction Strategy for DIA Human Gut Metaproteomics.

Genomics, proteomics & bioinformatics·2026

Same journal

SurvGME: an R package for survival analysis with graphical and measurement error models.

BMC bioinformatics·2026

Same journal

SimMapNet: a Bayesian framework for gene regulatory network inference using gene ontology similarities as external hint.

BMC bioinformatics·2026

Same journal

Dual channel drug-drug interactions extraction based on cross attention.

BMC bioinformatics·2026

Same journal

FeSseqdb: a curated sequence-level database and interpretable machine learning framework for identifying iron-sulfur proteins.

BMC bioinformatics·2026

Same journal

Benchmarking DNA barcode decoding strategies under high error rates.

BMC bioinformatics·2026

Same journal

pyVIPER: a fast and scalable Python package for protein activity estimation and master regulator analysis of single-cell RNA sequencing data.

BMC bioinformatics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 29, 2026

Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data

Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data

Published on: May 15, 2019

MetaTree: an interactive web platform for aligned hierarchical data visualization and multi-group comparison.

Qing Wu^1,2, Ailing Zhang^1,2, Zhibin Ning¹

¹Faculty of Medicine, School of Pharmaceutical Sciences, University of Ottawa, Ottawa, Canada.

BMC Bioinformatics

|May 28, 2026

Summary

This summary is machine-generated.

MetaTree is a new web platform for visualizing and comparing hierarchical data, like microbiome studies. It enables direct, topology-consistent comparisons across multiple samples and experimental groups, simplifying data analysis.

Keywords:

Heat-tree Hierarchical visualization MetaTree Topology-consistent comparison Web-based software

More Related Videos

A Practical Guide to Phylogenetics for Nonexperts

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

CorrelationCalculator and Filigree: Tools for Data-Driven Network Analysis of Metabolomics Data

CorrelationCalculator and Filigree: Tools for Data-Driven Network Analysis of Metabolomics Data

Published on: November 10, 2023

Related Experiment Videos

Last Updated: May 29, 2026

Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data

Using the Open-Source MALDI TOF-MS IDBac Pipeline for Analysis of Microbial Protein and Specialized Metabolite Data

Published on: May 15, 2019

A Practical Guide to Phylogenetics for Nonexperts

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

CorrelationCalculator and Filigree: Tools for Data-Driven Network Analysis of Metabolomics Data

CorrelationCalculator and Filigree: Tools for Data-Driven Network Analysis of Metabolomics Data

Published on: November 10, 2023

Area of Science:

Computational Biology
Bioinformatics
Microbiome Research

Background:

Hierarchical quantitative profiles are crucial in microbiome studies and other fields.
Comparing multiple samples and groups while maintaining hierarchical structure is difficult.
Existing methods often require manual figure assembly and lack aligned comparisons.

Purpose of the Study:

To develop an open-source platform for interactive visualization and comparative analysis of hierarchical quantitative data.
To address the challenges in comparing multiple samples and experimental groups within a shared hierarchy.
To facilitate the generation of publication-ready figures for hierarchical datasets.

Main Methods:

Developed MetaTree, an installation-free, browser-based platform.
Anchored samples, groups, and contrasts to a shared reference hierarchy for topology consistency.
Integrated statistical testing with false discovery rate (FDR) control for clade comparisons.
Implemented user-configurable controls for visual encoding, filtering, and layout.
Utilized interactive navigation, adaptive label handling, and branch collapsing for large hierarchies.

Main Results:

MetaTree provides topology-consistent visualization and comparison of hierarchical profiles.
The platform enables one-to-one node correspondence for aligned comparisons across views.
Users can identify clades with significant differences between conditions using integrated statistical testing.
Configurable controls allow adaptation of figures to various datasets and reporting needs.
Interactive features ensure usability for large and complex hierarchies.

Conclusions:

MetaTree is a web platform for topology-consistent visualization and comparison of hierarchical data.
It supports coordinated multi-panel exploration and automated comparison matrices.
Facilitates rapid generation of publication-ready figures for microbiome and other hierarchical datasets.