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Spermatogonial stem cell-based cellular therapy for non-obstructive azoospermia: a narrative review.
Maryam Salehi Novin1, Mehdi Mehdinezhad Roshan1, Omid Abouie Mehrizi1
1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Zygote (Cambridge, England)
|May 28, 2026
Summary
Spermatogonial stem cells (SSCs) are key to male fertility. SSC transplantation shows promise for treating male infertility and restoring sperm production, especially after treatments like chemotherapy.
Area of Science:
- Reproductive Biology
- Cell Biology
- Andrology
Background:
- Spermatogonial stem cells (SSCs) are crucial for male fertility, enabling continuous sperm production.
- Male infertility affects many men, with causes ranging from hormonal issues to genetic factors.
- Non-obstructive azoospermia (NOA) represents a severe form of infertility due to failed spermatogenesis.
Purpose of the Study:
- To review spermatogonial stem cell (SSC) transplantation as a therapeutic strategy.
- To explore the potential of SSCs in regenerating spermatogenesis in infertile men.
- To discuss SSC applications in patients with damaged fertility due to cancer treatments.
Main Methods:
- Review of existing literature on SSC biology and transplantation.
- Analysis of current treatments for male infertility, including micro-TESE.
- Exploration of the role of SSCs in fertility restoration.
Main Results:
- SSCs possess self-renewal and differentiation capabilities essential for sperm production.
- SSC transplantation is a potential avenue for treating infertility and NOA.
- SSCs offer a promising approach for fertility preservation and restoration post-cancer therapy.
Conclusions:
- Spermatogonial stem cell transplantation holds significant potential for treating male infertility.
- Restoring spermatogenesis via SSCs could benefit patients with NOA and those undergoing gonadotoxic therapies.
- Further research into SSC transplantation is warranted to establish its clinical efficacy.
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