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Pamidronate Dose Response for Hypercalcemia in Burn-Injured Patients
Gisoo Imani1, Erin Louie1, Sierra Young1
1Department of Pharmacy, University of California Davis Medical Center, Sacramento, CA, USA.
Summary
Intravenous pamidronate effectively reduced high calcium levels in burn patients. This treatment for hypercalcemia post-burn injury showed significant decreases in ionized calcium by day 14.
Area of Science:
- Burn injury management
- Endocrinology
- Pharmacology
Background:
- Hypercalcemia post-burn injury is linked to bone resorption from immobility.
- Limited evidence exists to guide treatment for this condition.
- This study aimed to evaluate pamidronate's effect on burn-related hypercalcemia.
Purpose of the Study:
- To assess the efficacy of intravenous pamidronate in managing hypercalcemia in burn patients.
- To determine the impact of pamidronate on ionized calcium levels post-burn injury.
Main Methods:
- Retrospective observational study at a regional burn center.
- Included adult burn patients receiving IV pamidronate for hypercalcemia.
- Primary outcome: change in ionized calcium (iCa) at 7 and 14 days post-treatment.
Main Results:
- Analyzed 37 treatment courses in 27 patients with a mean burn TBSA of 60.2%.
- Mean iCa decreased by -0.26 mmol/L (approx. 17%) at 7 and 14 days post-pamidronate.
- Hypocalcemia occurred in 13.5% of administrations.
Conclusions:
- Intravenous pamidronate appears effective in lowering ionized calcium levels in hypercalcemic burn patients.
- Further research is necessary to understand the clinical implications of these findings.
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