Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Oral Microbiota

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...

Biofilms

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Facile Fabrication and Stable Mechanism of a Microscale Heavy Calcium Carbonate Suspension.

Langmuir : the ACS journal of surfaces and colloids·2026

Same author

A Zinc-Coordinated Glycopolymer for Inhibiting Bacterial Toxins in Management of Acute Pneumonia.

ACS applied materials & interfaces·2026

Same author

A Photo-Driven Immune Modulator Combined with Chemo-Photothermal Therapy Blocks Immune Checkpoint for Helicobacter pylori Infection.

Advanced healthcare materials·2025

Same author

A Facile Coordination Polymer Nanoparticle for Sonodynamic Therapy Combating Drug-Resistant Bacteria.

Small (Weinheim an der Bergstrasse, Germany)·2025

Same author

Enhanced Photodynamic Therapy Synergizing with Neutrophil Recruitment Boosts Drug-Resistant Bacterial Clearance.

Advanced healthcare materials·2025

Same author

Supramolecular discrimination and diagnosis-guided treatment of intracellular bacteria.

Nature communications·2025

Search research articles

Related Experiment Video

Updated: May 31, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

A Decoy-Shedding Nanocoating Modulating the Pathogenic Niche for Dental Caries Prevention.

Ruiyao Wang¹, Hongyu Wang¹, Jie Li¹

¹Key Laboratory of Functional Polymer Materials of Ministry of Education, Tianjin Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.

ACS Applied Materials & Interfaces

|May 28, 2026

Summary

New decoy-shedding nanocoatings prevent dental caries by blocking bacterial adhesion. These stable coatings effectively inhibit Streptococcus mutans and reduce caries in rodent models without harming oral health.

Keywords:

adaptive protection anticaries material dental caries dental microenvironment enamel anchoring nanocoatings

More Related Videos

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Published on: January 7, 2019

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

Related Experiment Videos

Last Updated: May 31, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Published on: January 7, 2019

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

Area of Science:

Biomaterials Science
Dental Research
Nanotechnology

Background:

Dental caries, driven by acid from Streptococcus mutans (S. mutans), presents challenges due to limitations in current dental material stability and responsiveness.
Existing prevention strategies struggle with long-term efficacy and targeted action against cariogenic bacteria.

Purpose of the Study:

To develop and evaluate novel decoy-shedding nanocoatings for effective and stable caries prevention.
To investigate the mechanism of action, including bacterial adhesion inhibition and acid-triggered response.

Main Methods:

Development of decoy-shedding nanocoatings (rpCA and rpEA series) with stable enamel anchoring via phosphate-enamel Ca2+ coordination.
Assessment of nanocoating stability in simulated saliva fluid (SSF) for 7 days.
Evaluation of inhibition rates against S. mutans and bacterial adhesion in a rodent caries model.

Main Results:

Nanocoatings rpE1A1 and rpC1A2 demonstrated high inhibition rates against S. mutans (up to 95.3% and 92.0%) and stability in SSF for 7 days.
The decoy-shedding mechanism effectively blocked mucin-mediated bacterial adhesion.
Rodent models showed the rpE1A1 coating reduced bacterial adhesion by 91.8%, significantly lowered caries scores, and maintained oral microbiota balance.

Conclusions:

The developed nanocoatings offer stable anchoring, environmental responsiveness, and synergistic multi-mechanism effects for precision caries prevention.
Decoy-shedding nanocoatings represent a promising new strategy for combating dental caries.
These findings pave the way for advanced biomaterials in dental restorative and preventative applications.