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Published on: November 27, 2019
Toxic Hepatopathies
1Department of Veterinary Science, Martin-Gatton College of Agriculture, Food, and Environment, University of Kentucky Veterinary Diagnostic Laboratory, PO Box 14125, Lexington, KY 40512-4125, USA.
Abstract:
Equines are exposed to a variety of dietary phytotoxins, phytonutrients, pharmaceuticals, and other exogenous compounds (xenobiotics). The hepatobiliary system has major roles in xenobiotic metabolism and excretion and is of major importance in toxicology. Understanding possible sources of toxic compounds, circumstances of exposure, likely differentials, and diagnostic options can help practitioners arrive at a diagnosis in poisoning cases. Treatment of toxic hepatopathies is generally symptomatic and supportive. Antidotes and specific treatments rarely exist. Important exceptions are identification and removal of source material to prevent ongoing exposures and decontamination of recently exposed animals.
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