Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coronary macrovascular and microvascular involvement and their association with distinct circulating microRNA patterns: The ANFIBIO Study.

Atherosclerosis·2026
Same author

<i>De novo</i> COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection.

Frontiers in immunology·2026
Same author

Key factors of the deranged antiviral response in elderly patients with COVID-19: a machine-learning analysis.

GeroScience·2026
Same author

Transcriptomic Profiling Identifies TALAM1 and LINC00702 as HIV-1-Responsive lncRNAs in Microglia.

International journal of molecular sciences·2026
Same author

Sex Differences in Myocardial Injury: Clinical Characteristics, Outcomes, and Prognostic Implications.

Journal of clinical medicine·2026
Same author

Poor control of pulmonary viral replication in COVID-19 patients with early respiratory failure.

Anaesthesia, critical care & pain medicine·2026

Related Experiment Video

Updated: May 31, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Plasma miR-502-5p and coronary artery vasospasm: An exploratory study.

Lucía Matute-Blanco1, Miguel Sánchez-Rodríguez2, Juan Casanova-Sandoval1

  • 1Department of Cardiology, Hospital Universitari Arnau de Vilanova, Institut Català de la Salut, Lleida, Spain; Cardiac Physiology and Pathology Group, Institut de Recerca Biomèdica de Lleida Fundació Dr. Pifarré, IRBLleida, Lleida, Spain.

Clinica E Investigacion En Arteriosclerosis : Publicacion Oficial De La Sociedad Espanola De Arteriosclerosis
|May 28, 2026
PubMed
Summary

Plasma miR-502-5p shows potential as a biomarker for coronary artery vasospasm (CAV), a condition causing ischemia without obstructive coronary disease. Further validation is needed for this promising diagnostic marker.

Keywords:
Coronary artery vasospasmVasoespasmo de arteria coronariamiR-502-5pmicroRNA

More Related Videos

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
05:58

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

Published on: February 3, 2021

Measurement of Myocardial Lactate Production for Diagnosis of Coronary Microvascular Spasm
06:18

Measurement of Myocardial Lactate Production for Diagnosis of Coronary Microvascular Spasm

Published on: September 17, 2021

Related Experiment Videos

Last Updated: May 31, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
05:58

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

Published on: February 3, 2021

Measurement of Myocardial Lactate Production for Diagnosis of Coronary Microvascular Spasm
06:18

Measurement of Myocardial Lactate Production for Diagnosis of Coronary Microvascular Spasm

Published on: September 17, 2021

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Coronary artery vasospasm (CAV) causes myocardial ischemia in patients lacking obstructive coronary disease.
  • Current detection methods for CAV are limited by a lack of specific biomarkers.
  • MicroRNAs (miRNAs) are investigated as potential circulating biomarkers for CAV.

Purpose of the Study:

  • To investigate circulating microRNAs (miRNAs) as potential biomarkers for coronary artery vasospasm (CAV).
  • To assess the diagnostic and prognostic value of plasma miR-502-5p in patients with suspected CAV.

Main Methods:

  • Prospective, multicenter cohort study (ANFIBIO) including 70 patients undergoing coronary vasospasm testing.
  • Circulating miRNA profiling using RT-qPCR.
  • Statistical analysis including AUC, NRI, and IDI to evaluate miR-502-5p's clinical utility.

Main Results:

  • A significant association was found between undetectable plasma levels of miR-502-5p and the presence of CAV (60% of patients).
  • Plasma miR-502-5p demonstrated exploratory incremental value when added to a clinical model, improving AUC (0.74-0.81) and reclassification metrics (NRI=0.533; IDI=0.079).
  • Patients with CAV showed higher use of oral nitrates.

Conclusions:

  • Plasma miR-502-5p is associated with CAV in this cohort.
  • miR-502-5p shows exploratory potential to enhance clinical models for CAV detection.
  • Findings are hypothesis-generating and require validation in larger, independent cohorts.