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HORDB 2.0: a comprehensive dataset of peptide hormones
Chenxin Hu1, Yuye Ran1, Xingzhen Lao2
1China Pharmaceutical University, Nanjing, China.
Scientific Data
|May 28, 2026
Summary
HORDB 2.0 is a new, comprehensive dataset of peptide hormones and peptide hormone drugs. This resource supports research and therapeutic development in endocrinology and pharmacology.
Area of Science:
- Endocrinology
- Pharmacology
- Biochemistry
Background:
- Peptide hormones are crucial signaling molecules regulating metabolism, growth, development, and reproduction.
- Advances in detection and computation continuously identify novel peptide hormones with therapeutic potential.
Purpose of the Study:
- To present HORDB 2.0, an open-access, manually curated dataset of peptide hormones.
- To support systematic research and therapeutic development in the field of peptide hormones.
Main Methods:
- Manual curation of peptide hormone data.
- Integration of diverse annotations including sequence, activity, structure, and clinical data.
- Inclusion of pharmacokinetic parameters like IC50, EC50, ED50, and blood-brain barrier permeability.
Main Results:
- HORDB 2.0 contains 7,390 entries: 7,307 peptide hormones and 83 peptide hormone drugs.
- The dataset includes 372 marketed formulations with comprehensive annotations.
- Enriched data facilitates peptide modification and drug design.
Conclusions:
- HORDB 2.0 is an expanded and enriched resource for peptide hormone research.
- The dataset supports downstream applications in endocrinology, pharmacology, and peptide-based drug discovery.
- Facilitates advancements in understanding and utilizing peptide hormones for therapeutic purposes.
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