Related Experiment Video
Updated: May 31, 2026

03:57
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Primary hyperparathyroidism presenting as atraumatic bilateral hip fractures: a case report
Kevin McCarroll1,2, Aisling Carroll3, Finlay Brennan3
1Bone Health Unit, St James's Hospital, Dublin, Ireland. kmccarroll@stjames.ie.
Journal of Medical Case Reports
|May 29, 2026
Summary
Primary hyperparathyroidism (PHPT) can cause rare atraumatic hip fractures in older adults. Early diagnosis and screening for secondary osteoporosis causes are crucial for effective management.
Area of Science:
- Endocrinology
- Geriatrics
- Orthopedics
Background:
- Primary hyperparathyroidism (PHPT) affects up to 1.5% of older adults, increasing fracture risk.
- Atraumatic hip fractures are a rare but serious complication of PHPT.
Purpose of the Study:
- To report a case of atraumatic bilateral neck of femur fractures in an older female due to undiagnosed PHPT.
- To highlight the importance of investigating secondary causes of osteoporosis in elderly patients.
Main Methods:
- Case presentation of an 82-year-old woman with atraumatic hip fractures.
- Diagnostic workup including X-ray, CT, blood tests (calcium, PTH, vitamin D), and bone densitometry (DXA).
Main Results:
- The patient presented with displaced left and non-displaced right neck of femur fractures.
- Blood tests confirmed hypercalcemia, vitamin D deficiency, and elevated parathyroid hormone (PTH).
- DXA revealed severe osteoporosis with T-scores of -4.0 and -4.9.
Conclusions:
- Undiagnosed PHPT can lead to severe bone loss and rare atraumatic hip fractures.
- DXA screening and investigation for secondary osteoporosis causes are vital in older adults.
Related Concept Videos
Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
The Parathyroid Glands
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Hormones and Bone Tissue
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hyperthyroidism I: Introduction
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...