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Commentary: Targeting Inflammation and Fibrosis in Lipedema: The Potential Role of Glucagon-like Peptide-1 Receptor

C William Hanke1

  • 1Ascension St. Vincent Hospital, Indianapolis, Indiana.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|May 29, 2026
PubMed
Abstract

No abstract available in PubMed .

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Glucagon-like Receptor Agonists01:24

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Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...

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