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Microporous Annealed Particle Wound Matrix for Post-Mohs Defects: A Randomized Controlled Multicenter First-In-Human
Jennifer T Hau1, Stephanie J Martin2,3,4, Colleen A Roosa5
1Cypress Dermatology, Cypress, Texas.
Background:
Post-Mohs surgical wounds may be painful, slow to heal, and prone to scarring. Comparative data for advanced wound care biomaterials in this setting are limited.
Objective:
The aim of this study was to evaluate the safety of a flowable, synthetic, microporous annealed particle (MAP) wound matrix versus hydrocolloid dressing and explore effects on pain, wound healing, and scarring.
Materials And Methods:
In this multicenter randomized study, a flowable synthetic MAP wound matrix was applied immediately after surgery and compared with a hydrocolloid dressing (control). The primary endpoint was safety. Exploratory endpoints included pain, Wound Bed Score, time to granulation, time to closure, and scarring at 6 months.
Results:
Forty patients were randomized to receive the wound matrix (n = 26) or control (n = 14). The primary safety endpoint was met. Pain was low in both groups and numerically lower in the matrix group. The matrix group achieved a Wound Bed Scoreof 12 or greater 14 days earlier than control. Granulation and closure times were similar. Scarring scores were significantly better in the matrix group (p = .0027).
Conclusion:
The MAP wound matrix was safe, did not delay healing, improved early wound bed quality, and reduced scarring versus standard of care.
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