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Association between choroidal thickness and primary open angle glaucoma in highly myopic eyes
Pei-Yao Jin1,2,3, Min Tang2,3, Min-Wen Zhou2,3
1Department of Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, School of Medicine, Tongji University, Shanghai 200040, China.
International Journal of Ophthalmology
|May 29, 2026
Summary
In highly myopic eyes with diffuse chorioretinal atrophy, thicker macular choroidal thickness (CT) is linked to primary open angle glaucoma (POAG). This suggests different causes for POAG in various stages of myopic atrophic maculopathy.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Myopia Studies
Background:
- High myopia is a risk factor for various ocular pathologies.
- Primary open angle glaucoma (POAG) and myopic atrophic maculopathy (MAM) can coexist in highly myopic individuals.
- Understanding the relationship between choroidal thickness (CT) and POAG in different MAM categories is crucial.
Purpose of the Study:
- To investigate the association between choroidal thickness (CT) and primary open angle glaucoma (POAG).
- To analyze this relationship across diverse categories of myopic atrophic maculopathy (MAM) in highly myopic eyes.
Main Methods:
- An observational analytical case-control study involving highly myopic patients.
- Comprehensive ophthalmic examinations including optical coherence tomography (OCT) for CT measurement.
- Classification of eyes for POAG status and MAM category, followed by stepwise logistic regression.
Main Results:
- Among 418 highly myopic eyes, 13.88% had POAG.
- No significant difference in POAG prevalence across MAM categories (P=0.44).
- In diffuse chorioretinal atrophy, POAG eyes had thicker macular CT and thinner central corneal thickness; parafoveal inferior CT was independently associated with POAG (OR=1.017).
Conclusions:
- Increased macular CT is independently associated with POAG in highly myopic eyes with diffuse chorioretinal atrophy.
- This finding suggests distinct pathogenic mechanisms for POAG development in high myopia with varying degrees of MAM.
- Further research may elucidate specific pathways and inform targeted interventions.
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