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Related Experiment Video

Updated: May 31, 2026

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

Fresh Frozen vs Autologous Costal Cartilage in Rhinoplasty: A Meta-Analysis of Complication Rates.

Forrest Bohler, Ethan Dimock, Chris Liao

    Aesthetic Surgery Journal. Open Forum
    |May 29, 2026
    PubMed
    Summary

    Fresh frozen costal cartilage (FFCC) shows lower warping and revision rates in rhinoplasty compared to autologous costal cartilage (ACC). FFCC is a safe alternative, with similar infection and resorption rates, though more research is needed.

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    Area of Science:

    • Plastic Surgery
    • Regenerative Medicine
    • Biomaterials Science

    Background:

    • Fresh frozen costal cartilage (FFCC) offers advantages over autologous costal cartilage (ACC) in rhinoplasty, including reduced donor site morbidity and operative time.
    • Concerns persist regarding the complication profile of FFCC when compared to ACC.

    Purpose of the Study:

    • To conduct a meta-analysis comparing postoperative complication rates between FFCC and ACC in rhinoplasty.
    • To specifically evaluate differences in infection, warping, resorption, and revision surgery rates.

    Main Methods:

    • A systematic review adhering to PRISMA guidelines was conducted, searching major databases (MEDLINE, Embase, Web of Science, Scopus) from 1990 to 2025.
    • Included studies involved rhinoplasty using FFCC or ACC in cohorts of at least 5 patients, with data extracted on complications, demographics, and follow-up.

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    Last Updated: May 31, 2026

    Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
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  • Risk of bias was assessed using ROBINS-I, and pooled complication rates were calculated and compared between graft types.

    • Main Results:

    • Twenty-seven studies with 2137 ACC patients and 766 FFCC patients were analyzed.
    • FFCC demonstrated significantly lower rates of warping (1.2% vs. 3.9%) and revision surgery (1.3% vs. 3.4%) compared to ACC.
    • No significant differences were found in infection (1.7% vs. 2.3%) or resorption rates (1.2% vs. 1.9%) between the two graft types.

    Conclusions:

    • FFCC is a safe and effective alternative to ACC in rhinoplasty, exhibiting reduced warping and revision surgery rates.
    • There is no increased risk of infection or resorption with FFCC compared to ACC.
    • Further prospective, controlled studies are recommended to validate these findings and assess long-term outcomes.