Successful surgical management of CIC-DUX4 sarcoma of the chest wall

CIC-DUX4 sarcoma is a rare and aggressive undifferentiated small round cell sarcoma most commonly affecting young adults and typically managed with multimodal therapy including surgery and systemic chemotherapy. We report a case of a 40-year-old female who presented with a rapidly enlarging fungating mass of the left anterior chest wall. Imaging demonstrated a localized soft-tissue lesion without evidence of metastatic disease. The patient underwent wide local excision of the mass with en bloc resection of involved fascia at a rural critical access hospital. Pathology confirmed CIC-DUX4 sarcoma of the chest wall. Postoperative recovery was uneventful and the patient underwent close oncologic surveillance. Follow-up imaging at two years demonstrated no evidence of recurrence or metastasis. This case highlights the potential role of definitive surgical management for localized CIC-DUX4 sarcoma and demonstrates that complex oncologic surgery can be successfully performed in resource-limited rural settings.