Related Experiment Video

Updated: May 31, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

SPARC Drives Tubulointerstitial Fibrosis through Regulating the CBP-DOT1L Pathway

Huimin Jiang1, Qing Yang1, Kuo Wang1

  • 1Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, P.R. China.

International Journal of Biological Sciences
|May 29, 2026
PubMed
Summary

SPARC protein drives kidney fibrosis by stabilizing DOT1L, a key epigenetic regulator. Targeting the SPARC-CBP-DOT1L pathway offers a novel therapeutic strategy for chronic kidney disease (CKD).

Keywords:
CBPCKDDOT1LPTECsSPARCtubulointerstitial fibrosis

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