Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sampling Plans01:23

Sampling Plans

Sampling is a crucial step in analytical chemistry, allowing researchers to collect representative data from a large population. Common sampling methods include random, judgmental, systematic, stratified, and cluster sampling.
Random sampling is a method where each member of the population has an equal chance of being selected for the sample. It involves selecting individuals randomly, often using random number generators or lottery-type methods. For example, when analyzing the properties of a...
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
Sampling Methods: Overview01:06

Sampling Methods: Overview

A sample refers to a smaller subset representative of a larger population. In analytical chemistry, studying or analyzing an entire population is often impractical or impossible. Therefore, samples are used to draw inferences and generalize the whole population. The sampling method selects individuals or items from a population to create a sample. Standard sampling methods include random, judgemental, systematic, stratified, and cluster sampling. 
In analytical chemistry, the choice of sampling...
Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
Sampling Methods: Sample Types01:18

Sampling Methods: Sample Types

Sampling materials are classified into three main types: solid, liquid, and gas.
Solid samples include a variety of substances, such as sediments from water bodies, soil, metals, and biological tissues. Two standard methods for extracting sediments from water bodies are grab sampling and piston coring. Grab sampling involves using a device to collect a discrete sediment sample from the bottom of a water body with minimal disturbance. Grab samples do not always represent the entire area due to...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioactive Compound-Integrated Metal Nanoparticles Promote Wound Repair in Diabetic Conditions: Evidence from an Animal Study.

Applied biochemistry and biotechnology·2026
Same author

Enhanced Biosynthesis of Phenolics and Antioxidants by Marine Endophyte Penicillium rubens: Optimization and Bioactivity Evaluation.

Applied biochemistry and biotechnology·2026
Same author

Prevalence and determinants of anaemia among pregnant women using biomass fuel in rural Tamil Nadu: a cross-sectional study.

BMC pregnancy and childbirth·2026
Same author

Personal household air pollution exposure and SARS-CoV-2 antibody responses among women and infants: an analysis within the HAPIN trial.

Environment international·2026
Same author

Applied Nanobiotechnology for Vector-borne Disease Management: Drug Delivery, Diagnostics, and Sustainable Vector Control.

Applied biochemistry and biotechnology·2026
Same author

Association of polycystic ovarian syndrome with inflammatory single nucleotide polymorphism for IL-1 & IL-6 genes: A case-control study.

The Indian journal of medical research·2026

Related Experiment Video

Updated: May 31, 2026

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
09:33

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

Integrating Microsampling in Human Biomonitoring: Methodologies, Regulatory Frameworks, and Case Study Insights.

Karthikeyan Rajamani1, Senthamil Selvi Poongavanam2

  • 1Laboratory for Biomonitoring, Department of General Medicine, Centre for Global Health Research, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India.

Critical Reviews in Analytical Chemistry
|May 29, 2026
PubMed
Summary

Microsampling uses minimally invasive samples for human biomonitoring, offering scalable, cost-effective, and acceptable methods for population surveillance and exposure assessment.

Keywords:
Biomonitoringenvironmental exposuremicrosamplingpoint-of-care testingrisk assessment

More Related Videos

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

Related Experiment Videos

Last Updated: May 31, 2026

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
09:33

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

Area of Science:

  • Environmental Health Sciences
  • Analytical Chemistry
  • Biomarkers and Diagnostics

Background:

  • Human biomonitoring traditionally relies on invasive sampling methods, posing challenges in participant acceptance, logistics, and cost.
  • Advancements in microsampling techniques offer a promising alternative using non-invasive or minimally invasive biological samples.

Purpose of the Study:

  • To review analytical techniques, case studies, point-of-care (POC) integration, and applications of microsampling in human biomonitoring.
  • To highlight the comparability of microsampling data with conventional methods and its potential for global health surveillance.

Main Methods:

  • Compilation of analytical techniques including Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS), immunoassays, and electrochemical sensors.
  • Review of case studies (e.g., NHANES, HBM4EU) and strategies for integrating microsampling into point-of-care (POC) devices.
  • Analysis of data on storage stability, detection limits, and quality control for various microsampling matrices.

Main Results:

  • Microsampling data are recognized as comparable to conventional sampling by OECD harmonization efforts.
  • Validated workflows and POC integration strategies demonstrate practical applications for diverse biomonitoring scenarios.
  • Case studies showcase successful implementation in population surveillance, occupational monitoring, and remote settings.

Conclusions:

  • Microsampling significantly overcomes limitations of conventional biomonitoring, enhancing participant acceptability and reducing costs.
  • It offers improved scalability for global health surveillance and supports real-time monitoring through POC integration.
  • Microsampling represents a paradigm shift towards more accessible and efficient human biomonitoring.