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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

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Related Experiment Video

Updated: Jul 3, 2026

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

Bioactive Compound-Integrated Metal Nanoparticles Promote Wound Repair in Diabetic Conditions: Evidence from an

Senthamil Selvi Poongavanam1, Rajeshkumar Shanmugam2

  • 1Nanobiomedicine Lab, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, 602105, India. Senthamilselvi11792@gmail.com.

Applied Biochemistry and Biotechnology
|July 2, 2026
PubMed
Summary

Diabetic wound healing faces challenges due to poor drug delivery. Combining natural compounds with metallic nanoparticles enhances stability and effectiveness for better wound repair.

Keywords:
Diabetes mellitusNano formulationsNano particlesWound healing

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Published on: September 25, 2019

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Wound Healing Research

Background:

  • Diabetic wound healing is clinically challenging due to impaired healing dynamics.
  • Naturally derived bioactive molecules show therapeutic potential but suffer from poor solubility and bioavailability.
  • Metallic nanoparticles offer a solution as delivery vehicles to enhance stability and penetration.

Purpose of the Study:

  • To review advancements in nano-enabled bioactive formulations for diabetic wound healing.
  • To analyze mechanisms of action and physicochemical properties of these formulations.
  • To identify translational challenges and research gaps in the field.

Main Methods:

  • Literature review of recent advancements in nano-enabled bioactive formulations.
  • Analysis of preclinical studies in rodent and large-animal diabetic wound models.
  • Evaluation of synergistic effects of bioactive compounds and metallic nanoparticles.

Main Results:

  • Nanoformulations demonstrate improved angiogenesis, fibroblast proliferation, immune regulation, and oxidative stress modulation.
  • Metallic nanoparticles enhance stability, tissue penetration, and controlled release of bioactive compounds.
  • Synergistic effects observed in preclinical models show promise for diabetic wound healing.

Conclusions:

  • Integration of phytochemicals with nanotechnology shows substantial promise for accelerating diabetic wound repair.
  • Nano-enabled formulations can overcome limitations of natural compounds for clinical application.
  • Further research is needed to address translational challenges and bridge research gaps.