Related Experiment Video
Updated: May 31, 2026
Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
DIGEST Grades Remain Stable With Inclusion of Moderately Thickened Liquids in the Videofluoroscopic Examination in
Veena Kallambettu1,2, Folsom Maureen1,2, Jennifer Chapin1
1Aerodigestive Research Core Laboratory, The Ohio State University, Columbus.
Purpose:
The Dynamic Imaging Grade of Swallowing Toxicity (Version 2; DIGESTV2) is a videofluoroscopy (VF) scale that measures pharyngeal swallowing severity based on functional measures of swallowing safety and efficiency. Original validation is based on a standard VF testing protocol including thin liquid, puree, and solid consistencies. Given that thickened liquid bolus trials are common in VF clinical testing protocols, we sought to determine the agreement in DIGESTV2 grades with and without the inclusion of moderately thick liquid bolus trials on DIGESTV2 outcomes in people with amyotrophic lateral sclerosis (pALS).
Method:
This study represents a secondary analysis of VF examinations from a prospective longitudinal study conducted in 109 pALS. VF evaluations contained 10 barium trials spanning three International Dysphagia Diet Standardisation Initiative (IDDSI) levels (0-7). Duplicate, independent, and blinded ratings were completed. DIGESTV2 Efficiency and Safety grading was then completed under two conditions-with and without the inclusion of moderately thick liquid bolus trials into DIGESTV2 grading-to produce two sets of DIGESTV2 ratings for each VF study. Descriptives, percent agreement, and a weighted Cohen's kappa were performed on DIGESTV2 grades.
Results:
A total of 373 VF examinations were included in this analysis. DIGESTV2 grade percent agreement with and without IDDSI Level 3 was excellent for Safety (98.1%), Efficiency (93.8%), and Total (94.1%) grades. Kappa values for Safety, Efficiency, and Total grades were .96, .89, and .91, respectively, indicating excellent agreement across bolus trial inclusion methods.
Conclusions:
Standard inclusion of moderately thick liquid bolus trials did not significantly impact DIGESTV2 grading in this data set. These results add to the preliminary but growing evidence suggesting stability of DIGEST grading with alternate bolus protocols in another patient population.
Supplemental Material:
https://doi.org/10.23641/asha.32348451.
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