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Updated: May 31, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Sustainable mevalonate bioproduction: A comprehensive review of microbial biosynthesis and downstream processing
1College of Agriculture and Bioengineering, Heze University, Heze 274015, Shandong, China; Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, China; School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin 300072, China.
Abstract:
Mevalonate (MVA), a crucial metabolic intermediate in the MVA pathway, serves as an essential biosynthetic precursor for terpenoids and holds considerable industrial significance in the chemical engineering, pharmaceutical, food, and cosmetics sectors. While conventional chemical synthesis of MVA encounters substantial limitations, microbial biosynthesis emerges as a highly promising alternative owing to its inherent sustainability and cost-effectiveness. This review provides a systematic and comprehensive analysis of recent advances in MVA biosynthesis. First, the production capabilities of native producers and engineered heterologous hosts, including model strains and non-model chassis organisms, are summarized. Subsequently, approaches to improve MVA biosynthesis efficiency are outlined, encompassing metabolic engineering, as well as the development of mixed-culture systems and cell-free catalytic platforms. Downstream extraction technologies are also evaluated, with an examination of current methodologies and innovative techniques. Finally, the current challenges and future directions for sustainable MVA bioproduction have also been discussed.
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