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TXNDC15 suppresses lung adenocarcinoma progression by inducing NEK4-dependent G2/M entry blockade

Ying Wang1, Xin Feng2, Lei Yuan3

  • 1Department of Oncology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, 271000, China.

Biochemical and Biophysical Research Communications
|May 29, 2026
PubMed

Insights

Thioredoxin domain-containing protein 15 (TXNDC15) suppresses lung adenocarcinoma (LUAD) progression by inducing cell cycle arrest. Downregulation of TXNDC15 predicts better survival in LUAD patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Lung adenocarcinoma (LUAD) presents significant challenges due to its heterogeneity and poor prognosis.
  • The role of the Thioredoxin domain-containing (TXNDC) family, specifically TXNDC15, in LUAD pathogenesis is not well understood.

Purpose of the Study:

  • To investigate the role and mechanism of TXNDC15 in lung adenocarcinoma.
  • To determine the prognostic value of TXNDC15 in LUAD patients.

Main Methods:

  • Analysis of TXNDC15 expression in LUAD tissues.
  • Functional assays to assess the impact of TXNDC15 on cell proliferation and cell cycle.
  • Co-immunoprecipitation to identify interacting proteins of TXNDC15.

Main Results:

  • TXNDC15 expression is downregulated in LUAD tissues.
  • Reduced TXNDC15 expression correlates with better patient survival.
  • TXNDC15 suppresses LUAD cell proliferation by inducing G2/M phase arrest.
  • TXNDC15 interacts with NEK4 to regulate the G2/M checkpoint.

Conclusions:

  • TXNDC15 acts as a tumor suppressor in LUAD.
  • The TXNDC15-NEK4 interaction is a critical regulatory pathway in LUAD progression.
  • TXNDC15 may serve as a potential therapeutic target or prognostic biomarker for LUAD.
Keywords:
Lung adenocarcinomaNEK4TXNDC15Tumor suppressor

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