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Updated: May 31, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Resveratrol's hepatic symphony: conducting a multi-stage intervention in liver cancer's progression

Cui Guo1, Fang Cao2, Ling Zhou3

  • 1Department of Rheumatology and Immunology, First Affiliated Hospital of Army Military Medical University, Chongqing 400038, China; Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Chinese Journal of Natural Medicines
|May 29, 2026
PubMed

Insights

Resveratrol, a natural compound, shows therapeutic potential in liver diseases by targeting multiple pathways. It combats chronic hepatitis, liver fibrosis, and hepatocellular carcinoma (HCC) progression.

Area of Science:

  • Natural Product Chemistry
  • Hepatology
  • Oncology

Background:

  • Hepatocellular carcinoma (HCC) development involves chronic hepatitis, liver fibrosis, and cirrhosis.
  • Resveratrol, a natural polyphenol, exhibits antioxidant, anti-inflammatory, and anti-tumor properties.
  • Resveratrol demonstrates therapeutic effects in various liver diseases.

Purpose of the Study:

  • To elucidate the multi-stage mechanism of resveratrol in hepatocellular carcinoma (HCC) development.
  • To highlight resveratrol's multi-target regulation and treatment capabilities in liver diseases.

Main Methods:

  • Review of signaling pathways modulated by resveratrol in chronic hepatitis, liver fibrosis, and HCC.
  • Analysis of resveratrol's effects on viral replication, hepatocellular injury, hepatic stellate cell activation, and tumor growth.
  • Investigation of pathways including PI3K/Akt, NF-κB, MAPK, Hippo, Nrf2/Keap1, SIRT1, JNK, and p53.

Main Results:

  • Resveratrol interferes with viral replication and reduces hepatocellular injury via antioxidant and anti-inflammatory actions.
  • Resveratrol decelerates fibrosis by suppressing hepatic stellate cell activation and collagen production.
  • Resveratrol inhibits tumor growth, induces apoptosis, and reduces migration, invasion, and angiogenesis in advanced HCC.

Conclusions:

  • Resveratrol exhibits a multi-stage therapeutic mechanism in HCC development.
  • Resveratrol's multi-target regulation offers significant treatment potential for liver diseases.
  • This study presents a comprehensive view of resveratrol's role across different stages of liver disease progression.
Keywords:
Chronic hepatitisHepatic fibrosisLiver cancerPharmacologic actionResveratrol

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