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Related Concept Videos

Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...

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Related Experiment Video

Updated: May 31, 2026

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits
06:03

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Published on: July 21, 2023

SIRT7 Prevents Intervertebral Disc Degeneration by Inhibiting the NF-κB Pathway.

Dongxin Wang1,2,3,4, Zhili Yang1,2,3,4, Lei Li1,2,3,4

  • 1Department of Orthopedics, Lanzhou University Second Hospital, 730000 Lanzhou, Gansu, China.

Frontiers in Bioscience (Landmark Edition)
|May 30, 2026
PubMed
Summary

Sirtuin 7 (SIRT7) declines in intervertebral disc degeneration (IVDD). Overexpressing SIRT7 protects against nucleus pulposus cell apoptosis and extracellular matrix degradation by inhibiting the NF-κB pathway, offering a potential IVDD therapeutic strategy.

Keywords:
NF-κB pathwayapoptosisextracellular matrixintervertebral disc degenerationsirtuin7

More Related Videos

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
05:46

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

Related Experiment Videos

Last Updated: May 31, 2026

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits
06:03

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Published on: July 21, 2023

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
05:46

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

Published on: February 14, 2021

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Intervertebral disc degeneration (IVDD) involves nucleus pulposus (NP) cell apoptosis and extracellular matrix (ECM) degradation.
  • Sirtuin 7 (SIRT7) is involved in gene expression, stress adaptation, and DNA repair, but its role in IVDD is unclear.

Purpose of the Study:

  • To investigate the functional role of SIRT7 in IVDD pathogenesis.
  • To elucidate the molecular mechanisms underlying SIRT7's function in IVDD.

Main Methods:

  • Quantified SIRT7 levels in human/rat NP tissues and cells using IHC and qRT-PCR.
  • Assessed SIRT7 overexpression effects on oxidative stress, apoptosis, ECM turnover, and NF-κB activity in vitro.
  • Validated therapeutic potential in a rat IVDD puncture model using MRI and histopathology.

Main Results:

  • SIRT7 was downregulated in degenerated tissues and cells, correlating with increased NF-κB activation.
  • SIRT7 overexpression reduced oxidative stress, apoptosis, and ECM degradation in NP cells.
  • SIRT7 overexpression ameliorated IVDD in a rat model by inhibiting NF-κB signaling.

Conclusions:

  • SIRT7 expression decreases during IVDD progression.
  • SIRT7 overexpression protects NP cells and ECM by inhibiting the NF-κB pathway.
  • SIRT7 is a promising molecular target for IVDD therapeutics.