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Cardiac Valve Repair and Replacement: Are Transcatheter Options Here to Stay?
Samuel Rustem Panday1,2, Fatemeh Habibi Nameghi2, Federico Giacobbe3
1Department of Cardiology, King's College Hospital, SE5 9RS London, UK.
Insights
Transcatheter valve therapies offer safe and effective treatments for valvular heart disease (VHD) across a wider patient range. These minimally invasive options complement traditional surgery, improving patient care and outcomes.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Valvular heart disease (VHD) significantly impacts global health, causing substantial morbidity and mortality.
- Transcatheter therapies have revolutionized VHD management over the last two decades.
- These interventions are increasingly used across diverse patient risk profiles.
Purpose of the Study:
- To review the evolution and current role of transcatheter valve therapies.
- To compare transcatheter approaches with traditional surgical methods.
- To highlight the importance of multidisciplinary decision-making in VHD treatment.
Main Methods:
- Review of landmark trials and guideline endorsements for transcatheter therapies.
- Analysis of the integration of surgical and transcatheter approaches.
- Emphasis on patient selection based on individual factors.
Main Results:
- Transcatheter aortic valve implantation (TAVI), mitral transcatheter edge-to-edge repair (M-TEER), tricuspid transcatheter edge-to-edge repair (T-TEER), and transcatheter valve replacement (TTVR) are established treatments.
- Transcatheter therapies provide safe and effective options for older patients, including those with frailty or comorbidities.
- Surgery remains the gold standard for younger, low-risk patients requiring long-term durability.
Conclusions:
- Transcatheter therapies are expanding access to definitive VHD treatment.
- A multidisciplinary Heart Team approach is crucial for personalized treatment decisions.
- Advancements in technology and expertise will further refine integrated surgical and transcatheter strategies.
Abstract:
Valvular heart disease (VHD) affects millions worldwide and remains a major cause of morbidity and mortality, placing a substantial and growing burden on healthcare systems. Over the past two decades, transcatheter therapies have emerged to meet this challenge, transforming the management of aortic, mitral, and tricuspid valve disease. Initially developed for inoperable or high-risk surgical patients, procedures such as transcatheter aortic valve implantation (TAVI) and mitral transcatheter edge-to-edge repair (M-TEER) are now routinely offered across a broader risk spectrum. More recently, tricuspid therapies, including tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter valve replacement (TTVR), have emerged to address a significant unmet clinical need. With transcatheter interventions becoming more widely available, clinicians across general and acute medical specialities are increasingly likely to encounter patients before and after these procedures. Familiarity with these therapies will support better decision-making and coordinated care. This review summarises the evolution of transcatheter valve therapy, its role alongside surgery, and the evidence supporting its use. Surgery remains the gold standard for younger or low-risk patients, particularly where long-term durability is essential. Transcatheter therapies now offer safe and effective treatment for older patients, including those with frailty or significant comorbidity, supported by landmark trials, which have demonstrated favourable clinical outcomes in carefully selected populations and underpinned guideline endorsement across risk categories. The importance of the multidisciplinary Heart Team is emphasised, ensuring treatment decisions reflect individual anatomy, comorbidity burden, life expectancy, and procedural risk. As device technology, imaging, and procedural expertise continue to advance, the integration of surgical and transcatheter approaches will support more individualised care and broaden access to definitive treatment for patients across the clinical spectrum.
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