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Updated: Jun 1, 2026
04:54
Assessing Mineral Availability in Fish Feeds using Complementary Methods Demonstrated with the Example of Zinc in Atlantic Salmon
Published on: October 29, 2021
Structural Elucidation and Zinc Supplement Potential of the High-Bioavailability Oyster Peptide-Zinc Complex
Ximing Yang1,2, Rongyao Du1,2, Yijiu Zhang1,2
1State Key Laboratory of Marine Food Processing & Safety Control, School of Food Science and Technology, Dalian Polytechnic University, Dalian, China.
Journal of Food Science
|May 30, 2026
Summary
Developing oyster peptide-zinc complex (OPZ) offers a novel solution for zinc deficiency. This study optimized OPZ preparation, demonstrating its enhanced zinc bioavailability and effectiveness in restoring zinc levels in mice.
Area of Science:
- Biochemistry
- Nutritional Science
- Food Science
Background:
- Zinc deficiency presents a significant global health challenge.
- Existing zinc supplements have limitations; oysters offer a rich zinc source but are underutilized.
- Oyster peptide-zinc complex (OPZ) presents a dual solution for zinc supplementation and oyster valorization.
Purpose of the Study:
- To optimize the chelation process for oyster peptide-zinc complex (OPZ).
- To characterize the formed OPZ and evaluate its stability and bioavailability.
- To assess the efficacy of OPZ in ameliorating zinc deficiency in a mouse model.
Main Methods:
- Single-factor and response surface methodology were employed for process optimization.
- Multispectral analysis (e.g., FTIR, SEM) was used for characterization.
- In vivo studies in zinc-deficient mice assessed physiological and biochemical parameters.
Main Results:
- Optimal chelation parameters (time, temperature, pH, ratios) were determined, yielding a high chelation rate.
- Characterization confirmed OPZ formation, involving amino acid residues and peptide chain rearrangement.
- OPZ demonstrated superior acid stability, gastrointestinal resistance, and higher zinc bioavailability than zinc sulfate in mice, restoring physiological parameters and alleviating organ damage.
Conclusions:
- Optimized OPZ preparation is feasible and yields a stable, bioavailable zinc complex.
- OPZ effectively addresses zinc deficiency in vivo, showing promise for functional foods and health products.
- This research supports oyster value-added processing and the development of advanced zinc supplements.
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