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Correction: Intravenous thrombolysis for acute central retinal artery occlusion: Protocol for a systematic review and individual participant data meta-analysis of randomized controlled trials.

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Related Experiment Video

Updated: Jun 1, 2026

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
05:20

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

Published on: November 12, 2020

Acute retinal artery occlusions.

Étienne Bénard-Séguin1, Brian Mac Grory2, Nancy J Newman3

  • 1Department of Ophthalmology, Emory University, Atlanta, GA, United States.

Handbook of Clinical Neurology
|May 30, 2026
PubMed
Summary
This summary is machine-generated.

Sudden vision loss from acute retinal artery occlusion requires immediate stroke evaluation. While no definitive treatments exist, intravenous or intra-arterial thrombolysis shows promise within specific time windows.

Keywords:
Branch retinal artery occlusionCentral retinal artery occlusionEye strokeRetinal ischemiaThrombolysis

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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
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Published on: March 26, 2020

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Last Updated: Jun 1, 2026

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
05:20

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

Published on: November 12, 2020

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Area of Science:

  • Ophthalmology
  • Neurology
  • Emergency Medicine

Background:

  • Acute retinal artery occlusions cause sudden, painless monocular vision loss, mirroring cerebral strokes.
  • Diagnosis relies on fundus examination, photography, and optical coherence tomography.
  • Effective management necessitates collaboration between emergency, ophthalmology, and neurology teams.

Purpose of the Study:

  • To review current diagnostic and management strategies for acute retinal artery occlusions.
  • To evaluate the potential benefits of thrombolytic therapy in acute central retinal artery occlusion.
  • To emphasize the importance of prompt emergency medical services activation and stroke center evaluation.

Main Methods:

  • Review of current literature, meta-analyses, and expert recommendations.
  • Standard stroke evaluation protocols for patients presenting with acute vision loss.
  • Discussion of diagnostic modalities including fundus photography and OCT.

Main Results:

  • No current widely accepted therapies exist for acute retinal artery occlusions.
  • Conservative treatments like paracentesis, massage, and hemodilution are not beneficial.
  • Intravenous thrombolysis (tPA) within 4.5 hours or intra-arterial tPA within 6 hours may offer treatment benefits for central retinal artery occlusion.

Conclusions:

  • Prompt recognition and emergency medical services activation are crucial for patients with acute vision loss.
  • Patients require immediate transfer to stroke-affiliated centers for timely diagnosis and evaluation.
  • Ongoing trials on intravenous thrombolysis aim to establish definitive treatment guidelines for acute retinal artery occlusions.