Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel Vitreous Substitutes in Animal and Human Models: A Systematic Review.

BioMed research international·2026
Same author

CMR Detected Atrial Structural and Functional Remodeling in AF HFrEF: Ablation vs Medical Rate Control.

JACC. Clinical electrophysiology·2026
Same author

Regenerative Ophthalmology: A Paradigm Change.

American journal of ophthalmology·2026
Same author

Neurophysiological correlates of delayed recovery of consciousness in a critically ill patient with COVID-19 with repeated cardiac arrest.

British journal of anaesthesia·2026
Same author

Efficacy and outcomes of 360° laser retinopexy versus focal laser photocoagulation for retinal detachment.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026
Same author

Concurrent validity estimates for the accuracy of administrative data case definitions for uveitis in Ontario, Canada.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026
Same journal

Preface.

Handbook of clinical neurology·2026
Same journal

Foreword.

Handbook of clinical neurology·2026
Same journal

Fundus autofluorescence imaging.

Handbook of clinical neurology·2026
Same journal

The electroretinogram as a means to study the physiology of the retina.

Handbook of clinical neurology·2026
Same journal

Adaptive optics scanning light ophthalmoscopy.

Handbook of clinical neurology·2026
Same journal

Modeling the human retina in a dish: Advances and future directions.

Handbook of clinical neurology·2026
See all related articles

Related Experiment Video

Updated: Jun 1, 2026

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice
07:46

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice

Published on: October 6, 2023

Stem cell therapy in retinal disease.

Jessica Wang1, Tina Felfeli2, Brian G Ballios3

  • 1Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Donald K. Johnson Eye Institute, Department of Ophthalmology, University Health Network, Toronto, ON, Canada.

Handbook of Clinical Neurology
|May 30, 2026
PubMed
Summary
This summary is machine-generated.

Stem cell therapy offers a promising approach for retinal degenerative diseases. Clinical trials show safety and improved vision, with ongoing research advancing potential cures for vision loss.

Keywords:
Animal modelsCell therapyRegenerationRetinaRetinal diseaseRetinal organoidsStem cellTherapeutic delivery

More Related Videos

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye
05:09

Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye

Published on: November 25, 2012

Related Experiment Videos

Last Updated: Jun 1, 2026

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice
07:46

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice

Published on: October 6, 2023

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye
05:09

Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye

Published on: November 25, 2012

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Retinal degenerative diseases have limited regenerative capacity.
  • Stem cells can self-renew and differentiate into specialized retinal cells.
  • Current research focuses on retinal pigment epithelium (RPE) and photoreceptor regeneration.

Purpose of the Study:

  • To evaluate the potential of stem cell therapy for treating retinal degenerative diseases.
  • To assess the safety and efficacy of transplanted stem cells in preclinical models and clinical trials.
  • To explore advancements in stem cell culturing and redifferentiation for improved therapies.

Main Methods:

  • In vivo experiments in animal models (primarily mice).
  • Transplantation of stem cell-derived RPE cells, photoreceptors, and precursors.
  • Preclinical assessment of cell survival, tumorigenicity, immune rejection, integration, maturation, and functional recovery.
  • Clinical trials for various retinal diseases.

Main Results:

  • Stem cell-derived retinal cells survived long-term in animal models without adverse effects.
  • Transplanted cells integrated, matured, and formed connections with host retinal cells.
  • Preclinical studies demonstrated rescue of visual function.
  • Clinical trials confirmed safety and showed visual function improvement in some patients.

Conclusions:

  • Stem cell therapy shows significant potential for treating retinal degenerative diseases.
  • Preclinical success translates to promising clinical outcomes, including improved vision.
  • Advancements in stem cell technology and retinal organoid culturing are paving the way for future vision restoration therapies.