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Association between triglyceride levels and upper urinary tract calcium stones recurrence
Jiawen Yang1, Jun Cai1, Yinan Li1
1Department of Urology, Sir Run Run Hospital, Nanjing Medical University, 109 Longmian Road, Jiangning District, Nanjing, 211100, Jiangsu Province, China.
BMC Nephrology
|May 30, 2026
Summary
High triglyceride levels increase the risk of kidney stone recurrence. This study found a significant association between elevated serum triglycerides and a higher likelihood of upper urinary tract calcium stone formation.
Area of Science:
- Nephrology
- Metabolic Disorders
- Urology
Background:
- Triglyceride (TG) is a recognized risk factor for kidney stones.
- The association between TG levels and kidney stone recurrence is not well-established.
- This research focuses on upper urinary tract calcium stones.
Purpose of the Study:
- To investigate the relationship between serum TG levels and the recurrence of upper urinary tract calcium stones.
- To determine if elevated TG levels are predictive of stone recurrence.
- To explore the dose-response relationship between TG and stone recurrence.
Main Methods:
- Retrospective enrollment of 303 patients with upper urinary tract calcium stones.
- Multivariable logistic regression to assess the association between TG and recurrence.
- Restricted cubic spline analysis for dose-response evaluation.
- Subgroup and sensitivity analyses for robustness.
Main Results:
- The overall recurrence rate was 45.54%.
- Higher TG quartiles showed increased recurrence rates, with the highest quartile (Q4) exhibiting a 2.98-fold increased risk.
- A linear dose-response relationship between TG levels and stone recurrence was observed.
- Findings were robust across sensitivity analyses.
Conclusions:
- Elevated serum triglyceride levels are significantly associated with an increased risk of calcium stone recurrence.
- TG levels may serve as a predictive marker for kidney stone recurrence.
- Further research into managing TG levels for stone prevention is warranted.
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