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Updated: Jun 1, 2026
![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Copper-Catalyzed Functionalization of C(sp2)-H Bonds with Vinyl Cations: Synthesis of Polycyclic Pyrroles
Yu Wang1,2, Hua-Hong Chen1,2, Maxim A Novikov3
1Fujian Key Laboratory of Chemical Biology and State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Abstract:
Catalytic C(sp2)-H functionalization of vinyl cations is an efficient protocol for the construction of new aromatic systems. However, most current methods suffer from noble metal catalysis and low atom economy. Herein, we report a copper-catalyzed C(sp2)-H functionalization of arenes with vinyl cations by a diyne cyclization strategy, leading to the concise synthesis of polycyclic pyrroles. This C(sp2)-H functionalization tolerates both electron-rich and -deficient arenes. Moreover, the related catalytic atroposelective C(sp2)-H functionalization can be realized by chiral copper catalysis.
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