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Related Concept Videos

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 1, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Small interfering RNA (siRNA)-based targeting breast cancer therapy.

Amin Talebi1, Afshin Khorrami2, Farshid Oruji3

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Daneshghah Ave, Tabriz, Iran.

Discover Oncology
|May 31, 2026
PubMed
Summary

Small interfering RNA (siRNA) therapy shows promise for breast cancer (BC) treatment by targeting cancer genes. Effective delivery systems like nanoparticles are crucial for its success and overcoming drug resistance.

Keywords:
Breast cancerTargeted therapysiRNAsiRNA delivery

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MISSION esiRNA for RNAi Screening in Mammalian Cells
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Last Updated: Jun 1, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

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Published on: May 30, 2025

MISSION esiRNA for RNAi Screening in Mammalian Cells
15:31

MISSION esiRNA for RNAi Screening in Mammalian Cells

Published on: May 12, 2010

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

Area of Science:

  • Oncology
  • Molecular Biology
  • Nanotechnology

Background:

  • Breast cancer (BC) necessitates innovative therapies due to its global health impact.
  • Current treatments face challenges including drug resistance and limited efficacy.

Purpose of the Study:

  • To analyze the benefits and drawbacks of siRNA therapy for breast cancer.
  • To evaluate targeted delivery systems for siRNA, including liposomes and nanoparticles.
  • To explore siRNA's potential in overcoming drug resistance and enhancing treatment efficacy.

Main Methods:

  • Literature review of siRNA mechanisms and applications in BC.
  • Analysis of nanoparticle-based delivery systems (liposomes, carbon, metal nanoparticles).
  • Investigation into challenges such as delivery efficiency, immunogenicity, and off-target effects.

Main Results:

  • siRNA selectively suppresses cancer-associated genes, impacting tumor initiation and progression.
  • Nanoparticles show potential as effective carriers for targeted siRNA delivery.
  • siRNA may help mitigate drug resistance and improve treatment outcomes.

Conclusions:

  • siRNA-based therapy holds transformative potential for breast cancer treatment.
  • Further research into delivery systems and safety is essential for clinical translation.
  • Development of enhanced, personalized therapeutic interventions for BC is the ultimate goal.