Related Experiment Video
Updated: Jun 2, 2026
07:03
In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease
Published on: July 19, 2024
Cardiovascular Disease Risk Prediction in Patients With Metabolic Dysfunction-Associated Steatohepatitis
Joe Hollinghurst1, Margarida Augusto2, Fotis Tefos2
1Health Economics and Outcomes Research Ltd, Cardiff, UK.
Diabetes, Obesity & Metabolism
|May 31, 2026
Summary
New models predict cardiovascular disease (CVD) risk in patients with metabolic dysfunction-associated steatohepatitis (MASH). These models offer improved accuracy over existing algorithms for better MASH patient management.
Area of Science:
- Cardiology
- Hepatology
- Data Science
Background:
- Metabolic dysfunction-associated steatohepatitis (MASH) significantly elevates cardiovascular disease (CVD) risk.
- Increased CVD morbidity and mortality are observed in MASH patients.
Purpose of the Study:
- To develop novel prediction models for CVD risk specifically in a MASH patient cohort.
- To establish the first predictive tool for CVD risk tailored to individuals with MASH.
Main Methods:
- Retrospective cohort study utilizing the UK Clinical Practice Research Datalink (CPRD) database.
- Accelerated failure time (AFT) models were employed for CVD risk prediction in male and female MASH patients.
- Inclusion of QRisk3 algorithm covariates and assessment of model calibration and discrimination.
Main Results:
- Developed CVD risk prediction models for 10,461 MASH patients (5364 female, 5097 male) with moderate predictive power (C-statistics 0.7-0.72).
- Identified age, cholesterol ratio, type 2 diabetes, and chronic kidney disease (CKD) as key risk factors impacting time to CVD.
- AFT models demonstrated superior accuracy in predicting CVD risk compared to the QRisk3 algorithm within the MASH cohort.
Conclusions:
- Introduced a pioneering predictive model for assessing CVD risk in MASH patients.
- The developed model holds potential for enhancing the precision of treatment and management strategies for MASH populations.
Related Concept Videos
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
01:26Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
01:24Overview of Lipid Metabolism
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
01:24Cirrhosis II: Pathophysiology
Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
01:14Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
In pharmacotherapy, monitoring drug concentrations is paramount, especially for drugs whose therapeutic effects hinge on both the active compound and its metabolite. Hepatic impairment profoundly influences drug potency by altering liver function. If the drug is more potent than its metabolite, impaired liver function amplifies drug activity due to elevated drug concentration levels. Conversely, if the metabolite holds greater potency, diminished liver function diminishes drug activity by...