Relationship Between the Cumulative Atherogenic Index of Plasma Exposure and Incident Heart Failure

We aimed to characterize the relationship between cumulative exposure to atherogenic index of plasma (AIP) and the risk of incident heart failure (HF) in a Chinese population.A total of 57,156 individuals extracted from the Kailuan study database were included in the current study. The cumulative atherogenic index of plasma (cum-AIP) was calculated as a weighted sum of the mean AIP values, and it quantifies a time-weighted cumulative exposure to AIP. Participants were divided into 4 groups based on the quartiles of cum-AIP or the duration of high AIP exposure. The Kaplan-Meier method was utilized to estimate the cumulative incidence of incident HF. The association between cumulative exposure to AIP and the risk of HF was assessed using adjusted Cox proportional hazards models. A sensitivity analysis was conducted to evaluate the robustness of the findings by excluding specific participants.A total of 1,434 incident HF cases were recorded over a median follow-up duration of 11.10 years. The incidence rates and cumulative incidences of HF exhibited a significant increase in the upper quartiles of cum-AIP and longer duration of high AIP exposure. Cox proportional hazards analysis revealed that individuals in the upper quartiles of cum-AIP or those with longer high AIP exposure duration showed elevated risks of incident HF.Cum-AIP and the duration of high AIP exposure are associated with the risk of incident HF. These findings may primarily reflect ischemic mechanisms of HF, as HF etiology was not differentiated in the present study.