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Quantifying Weight Loss Prior to Pancreatic Cancer Diagnosis: A Systematic Review and Meta-Analysis
Claire A Price1,2, Debbie Cooke1, Freda Mold1
1University of Surrey, School of Health Sciences, Surrey, UK.
Cancer Medicine
|May 31, 2026
Summary
Pancreatic cancer patients lose an average of 5.9 kg before diagnosis. This quantitative data on weight loss and BMI change can improve early detection models and clinical practice.
Area of Science:
- Oncology
- Metabolic Medicine
- Epidemiology
Background:
- Pancreatic cancer is often diagnosed late due to non-specific symptoms like weight loss.
- Precise quantification of pre-diagnostic weight loss could improve diagnostic utility.
Conclusions:
- This meta-analysis provides crucial reference values for weight loss in pancreatic cancer.
- Findings support the integration of quantitative weight loss data into early detection strategies.
- Moderate certainty of evidence due to high heterogeneity necessitates cautious interpretation.
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