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Related Experiment Video

Updated: Jun 2, 2026

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis
04:47

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Published on: October 27, 2023

Acute Motor Axonal Neuropathy Coexisting With Ankylosing Spondylitis: A Case-Based Review.

Yiğit Can Güldiken1, Batool Achmar2, Sema Kaymaz Tahra3

  • 1Department of Neurology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Türkiye, comu.edu.tr.

Case Reports in Immunology
|June 1, 2026
PubMed
Summary
This summary is machine-generated.

This case study presents a rare instance of Guillain-Barré syndrome (GBS), specifically acute motor axonal neuropathy (AMAN), co-occurring with ankylosing spondylitis (AS) without apparent triggers. Plasma exchange therapy showed positive results in improving symptoms.

Keywords:
Guillain Barre syndromeacute axonal motor neuropathyankylosing spondylitisidiopathic autoimmune disorders

Related Experiment Videos

Last Updated: Jun 2, 2026

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis
04:47

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Area of Science:

  • Neurology
  • Immunology
  • Rheumatology

Background:

  • Guillain-Barré syndrome (GBS) is an autoimmune disorder affecting peripheral nerves, with acute motor axonal neuropathy (AMAN) being a subtype.
  • Ankylosing spondylitis (AS) is a chronic inflammatory condition primarily affecting the spine and sacroiliac joints.
  • A known association exists between anti-TNF α medication and GBS, typically in patients treated for AS.

Purpose of the Study:

  • To report a unique case of co-occurring AMAN and AS in a patient without prior therapeutic or infectious triggers.
  • To highlight the diagnostic challenges and management of this rare dual diagnosis.

Main Methods:

  • Clinical presentation of a 35-year-old male with limb paralysis and normal reflexes.
  • Diagnostic workup including electromyography (EMG) for neuropathy assessment.
  • Lumbar puncture for cerebrospinal fluid analysis (high protein, normal cell count).
  • Human leukocyte antigen (HLA)-B27 testing and magnetic resonance imaging (MRI) for sacroiliitis detection.

Main Results:

  • Diagnosis of AMAN confirmed by EMG and lumbar puncture findings.
  • AS diagnosis supported by positive HLA-B27 and MRI evidence of bilateral sacroiliitis.
  • Patient experienced improved bulbar function following plasma exchange (PLEX) treatment.

Conclusions:

  • The co-occurrence of AMAN and AS can happen spontaneously, challenging the established link solely through anti-TNF α therapy.
  • This case underscores the importance of comprehensive diagnostic evaluation for patients presenting with overlapping neurological and rheumatological symptoms.
  • PLEX demonstrated efficacy in managing the neurological deficits associated with AMAN in this context.