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Revisiting viral reprogramming: Measles virus as a robust platform for high-quality iPSC generation

Mohamed Taha Moutaoufik1, Mohamed Chahine2,3

  • 1Faculty of Medical Sciences, UM6P Hospitals, Mohammed VI Polytechnic University, Ben Guerir, Morocco.

Molecular Therapy. Advances
|June 1, 2026
PubMed
Abstract

No abstract available in PubMed .

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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