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Updated: Jun 2, 2026
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Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
Published on: March 29, 2022
Early choroidal thickness changes predict myopia control response to peripheral defocus spectacles in premyopic
Qian Wang1, Qing Lu1, Xiaoxia Chen1
1Department of Ophthalmology, Shanghai Yangpu District Shidong Hospital, Shanghai, China.
Summary
Early changes in choroidal thickness predict treatment response to peripheral defocus spectacles in children. Three-month subfoveal choroidal thickness changes can guide personalized myopia control interventions.
Area of Science:
- Ophthalmology
- Pediatric Optometry
- Myopia Control Research
Background:
- Peripheral defocus spectacles are used to manage myopia progression in children.
- Predicting treatment response early is crucial for effective myopia management.
Purpose of the Study:
- To determine if early changes in choroidal thickness predict long-term response to peripheral defocus spectacles.
- To assess the predictive value of subfoveal choroidal thickness (SFCT) changes for axial length (AL) outcomes.
Main Methods:
- A randomized controlled trial involving 200 children aged 6-8 years with premyopia.
- Comparison of peripheral defocus spectacles (PDS) versus single vision spectacles (SVS).
- Measurement of SFCT and AL using swept-source optical coherence tomography over 12 months.
Main Results:
- PDS significantly reduced AL elongation (41% efficacy) and myopia incidence compared to SVS.
- Early SFCT changes at 3 months predicted 12-month AL outcomes (AUC=0.76).
- Children with early SFCT thickening showed superior AL control.
Conclusions:
- Peripheral defocus spectacles are effective in controlling myopia progression in premyopic children.
- Three-month SFCT changes serve as a reliable early biomarker for treatment response.
- Early identification of optimal responders allows for timely personalized interventions in myopia management.
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