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Post-Viral Aspergillosis: A Systematic Review of Incidence, Clinical Manifestations, and Outcomes

Mandana Akhavan1,2, Sadegh Khodaveisi1,2,3, Saba Akbarzadeh2

  • 1Division of Molecular Biology, Medical Mycology and Parasitology Department, School of Public Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Reviews in Medical Virology
|June 1, 2026
PubMed

Insights

Post-viral aspergillosis (PVA) is a dangerous complication following respiratory viral infections, especially in critically ill patients. Early diagnosis and antifungal treatment are crucial for improving outcomes in these vulnerable individuals.

Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Critical Care Medicine

Background:

  • Invasive aspergillosis (IA) traditionally affects immunocompromised individuals.
  • Post-viral aspergillosis (PVA) is an emerging complication after viral infections, notably during the COVID-19 pandemic.
  • PVA impacts patients with various respiratory viral infections.

Conclusions:

  • Timely diagnosis of PVA is critical for patient outcomes.
  • Early initiation of appropriate antifungal therapy is essential for managing PVA.
  • Aspergillus requires specific culture conditions, emphasizing diagnostic diligence.
Keywords:
invasive aspergillosispost‐viral aspergillosisrespiratory viral infectionsviral‐associated pulmonary aspergillosis

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