To describe the editorial, methodological, and thematic typology of biomedical publications in the journal "La Tunisie Médicale" (Tunis Med) over a 20-year period.

This was a bibliometric study of publications in Tunis Med (ISSN 0041-4131) between 2000 and 2019, based on MEDLINE consultation (via Web of Science), using MeSH descriptors, in the two decades A (2000-2009) and B (2010-2019).

Between 2000-2019, 4,135 publications (A=1,989;B=2,146) were published by Tunis Med by 12,402 authors (A=6,156;B=8,150), and indexed by 5,153 MeSH descriptors (A=3,554;B=3,616). Classified mainly in the research areas "Pediatrics" (30%) and "Geriatrics/Gerontology" (26%), their "MeSH Qualifiers" were mainly clinical: "diagnosis" (37%), "Etiology" (28%) and "Complications" (24%). While writing in English increased considerably (A=8%;B=54%), the measures "Survival" (A=29;B=16) and "Multivariate Analysis" (A=9;B=11) continued to be little applied. Biological factors ("Pregnancy", "Age", "Consanguinity") and those associated with health systems ("Hospitalization", "Patient Satisfaction", "Length Of Stay") were the most studied health determinants. Neoplastic and cardiovascular diseases were the most explored health problems, including "Lung Neoplasms" (A=32;B=51), «Kidney Neoplasms» (A:10; B:25), "Bone Neoplasms" (A=17;B=28), "Hypertension" (A=31;B=26), "Myocardial Infarction" (A=26;B=15), and "Heart Failure" (A=16;B=7). The most explored surgical procedures were: "Laparoscopy" (A=33;B=31), "Cesarean Section" (A=21; B=15), and "Kidney Transplantation" (A=10;B=14).

Between 2000-2019, Tunis Med publications focused on non-communicable diseases. Despite transitioning to English, they rarely employed advanced statistical measures and high-level evidence-based study designs. Strengthening their methodological approaches is essential to enhance the journal's international visibility and reputation.