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Updated: Jun 3, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Palladium-Catalyzed Enantioselective Decarboxylative Hydrobenzylation of Allenes with Aryl Acetic Acids
Jian-Bin Lu1, Qiao-Yang Liu1, Qian-Qian Yang2
1Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Abstract:
We report a palladium-catalyzed asymmetric hydrobenzylation reaction of alkoxy- and amidoallenes with aryl acetic acids by in situ forming labile acetal-type intermediates, and a diverse array of enantioenriched allylic ethers and amides bearing a homobenzylic stereogenic center are finally afforded after decarboxylation.
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