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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 3, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Published on: June 13, 2014

Tumor-Tropic Bacterial-Nanoparticle Hybrids for Metabolic Reprogramming and Cancer Immunotherapy.

Ping Ji1,2,3, Chujie Lin3, Jiaxin Wang1

  • 1Department of Nuclear Medicine, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, China.

ACS Nano
|June 1, 2026
PubMed
Summary

This study introduces a novel bacterial-nanoparticle hybrid therapy that reprograms tumor metabolism and boosts immune response for effective cancer treatment. The innovative approach significantly inhibits tumor growth and converts cold tumors into hot ones, enhancing immunotherapy outcomes.

Keywords:
bacteria-mediated deliverybiohybrid systemcancer immunotherapymetabolic reprogrammingtumor microenvironment reprogramming

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Area of Science:

  • Oncology
  • Immunology
  • Nanotechnology
  • Microbial Therapy

Background:

  • Solid tumors exhibit metabolic dysregulation and immune suppression, hindering effective cancer treatment.
  • Simultaneously reprogramming tumor metabolism and restoring antitumor immunity presents a significant therapeutic challenge.

Purpose of the Study:

  • To develop a novel tumor-tropic bacterial-nanoparticle hybrid (SW@CDFM) for synergistic cancer treatment.
  • To investigate the potential of SW@CDFM in reprogramming tumor metabolism and activating antitumor immunity.

Main Methods:

  • Constructed a biohybrid system by conjugating *Shewanella oneidensis* bacteria with tumor cell membrane-camouflaged DOX-Fe/CpG nanoparticles.
  • Utilized the hypoxia tropism of *Shewanella* for selective tumor accumulation.
  • Assessed metabolic reprogramming, immune activation, and therapeutic efficacy in murine cancer models.

Main Results:

  • SW@CDFM selectively accumulated in tumors, alleviating acidosis and remodeling the tumor microenvironment's metabolic landscape.
  • Doxorubicin and CpG release induced immunogenic cell death and activated dendritic cells, promoting a robust immune cascade.
  • Combination therapy with αPD-1 checkpoint blockade achieved over 90% tumor growth inhibition and converted "cold" tumors to "hot" ones.

Conclusions:

  • The SW@CDFM biohybrid system effectively synergizes microbial therapy and nanotechnology for cancer treatment.
  • This approach successfully reprograms tumor metabolism and restores antitumor immunity, overcoming biological barriers.
  • Establishes a paradigm for designing advanced biohybrid systems for enhanced cancer immunotherapy.