Related Experiment Video

Updated: Jun 3, 2026

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

Left ventricular diastolic dysfunction in preterm infants with bronchopulmonary dysplasia

Nilkant Phad1,2, Ryan Woodford3, Koert de Waal4,3

  • 1John Hunter Children's Hospital, Newcastle, NSW, Australia. nilkant.phad2@health.nsw.gov.au.

Journal of Perinatology : Official Journal of the California Perinatal Association
|June 1, 2026
PubMed

Insights

Infants with bronchopulmonary dysplasia (BPD) show higher rates of pulmonary hypertension (PH) and left ventricular diastolic dysfunction (LVDD). Echocardiography can screen for these conditions in infants with BPD.

Area of Science:

  • Neonatal cardiology
  • Pediatric pulmonology
  • Cardiovascular imaging

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease in preterm infants.
  • Left ventricular diastolic dysfunction (LVDD) can occur in infants with BPD.
  • Early identification of LVDD is crucial for management.

Purpose of the Study:

  • To screen infants with BPD at 36 weeks postmenstrual age for LVDD.
  • To evaluate the utility of echocardiographic algorithms for diagnosing LVDD and PH in BPD.

Main Methods:

  • Utilized conventional Doppler and myocardial deformation parameters based on the American Society of Echocardiography algorithm.
  • Assessed left ventricular (LV) function and diagnosed pulmonary hypertension (PH) using specific parameters.
  • Applied age-appropriate cut-off values to identify and grade LVDD.

Main Results:

  • Analyzed scans from 71 control infants and 93 infants with BPD.
  • Pulmonary hypertension (PH) was detected in 15% of BPD infants versus 7% of controls.
  • Grade 2 LVDD was observed in 5% of BPD infants compared to 1.4% of controls.

Conclusions:

  • Infants with moderate to severe BPD exhibit a significantly higher incidence of PH and grade 2 LVDD.
  • Echocardiographic assessment aids in early detection of diastolic dysfunction in BPD.
  • Findings highlight the importance of cardiac screening in infants with BPD.
Abstract

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